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An estrogen ester is an ester of an endogenous, steroidal estrogen, generally estradiol but also estrone or estriol. Esterification renders these drugs into metabolically-resistant prohormones of their respective parent estrogen, improving oral bioavailability, increasing lipophilicity, and extending half-life (which necessitates less frequent administration). In addition, with intramuscular injection, they are absorbed more slowly into the body, further improving half-life.〔 Estrogen esters are used in hormone replacement therapy and as hormonal contraceptives, among other indications. The first estrogen ester to be marketed was estradiol benzoate in 1936, which was quickly followed by many more. ==List of estrogen esters== Many esters of estradiol have been marketed, including the following: * Atrimustine (Bestrabucil) * Cloxestradiol (Genovul) * Estradiol acetate (Femring, Femtrace, Menoring) * Estradiol benzoate (Agofollin, Diffolisterol, Progynon-B) * Estradiol butyrylacetate (Follikoside) * Estradiol cypionate (Depo-Estradiol, Depofemin, Estradep) * Estradiol dipropionate (Agofollin, Diovocyclin, Progynon-DP) * Estradiol diundecylate (Estrolent, Etrosteron, Theramex) * Estradiol enanthate (Anafertin, Deladroxate, Perlutan, Topasel, all in combination with dihydroxyprogesterone acetophenide) * Estradiol furoate (Di-folliculine) * Estradiol hemisuccinate (Eutocol) * Estradiol hexahydrobenzoate (Benzo-Ginoestril, Ginestryl-15-depot, Menodin, Tardoginestryl) * Estradiol monopropionate (Acrofollin, Akrofollin, Follhormon) * Estradiol palmitate (Esmopal) * Estradiol propoxyphenylpropionate (Durovex) * Estradiol stearate (Depofollan) * Estradiol undecylate (Delestrec, Depogin, Primogyn Depot, Progynon Depot) * Estradiol valerate (Altadiol, Deladiol, Delestrogen, Estraval, Progynova, Valergen) * Estramustine (Emcyt, Estracit) * Trimethyl estradiol acetate (Estrotate) As well as the following esters of other estrogens:〔〔 * Estriol diacetate benzoate (Holin-Depot) * Estriol sodium succinate (Pausan, Styptanon) * Estriol succinate (Sinapause, Styptanon, Synapause) * Estriol tripropionate (Estriel) * Estrone acetate (Hovigal) * Estrone sulfate (as the primary component of Premarin) * Estrone tetraacetylglucoside (Glucovex, Glycovex) * Estropipate (Ogen, Ortho-Est) A few other estrogen esters which are notable but have not been marketed include estrapronicate and orestrate, which are estradiol esters.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Estrogen ester」の詳細全文を読む スポンサード リンク
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